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Patrick Genetics
Written by Erik Paul Gulbrandsen   
Wednesday, 06 September 2006

 Dr. Patrick's lectures came out of the Thompson and Thompson genetics book (even though it wasn't the required genetics book) last year--his notes don't seem to have changed one bit. There are a couple of charts in that book that are very worthwhile. It is the charts that talk about the genetic inheritance patterns and what the characteristics are (Autosomal dominant, recessive, etc...). I wouldn't really read anything in the book except for those charts. The Carlson textbook has some awesome diagrams of mitosis and meiosis. I would DEFINATELY take the statements that Dr. Patrick talks about in his notes (where does Meiosis I arrest in female, or where does Meiosis II arrest in Females) and write it in the book on the timeline. These two drawings are in the second chapter, I think.

What Dr. Patrick thinks is unique is really a reflection of him as a person (as is the case with every professor). SO, if there is some reference in the notes to some thing that seems "interesting" (would Dr. Patrick talk about it at a bar), then I would at least clue in on it. I don't really remember test questions, so, don't assume this was an old question (it is an honor code violation for anybody to give out old test questions)--looking at your notes just briefly, I saw RFLPS and O.J. Simpson. That seems kinda odd, almost like something Dr. Patrick would find enjoyable to talk about, so I would keep that tucked in the back of my mind. If I remember properly, RFLPS is a way to do genetic testing (been a while--no laughing). That is just a quick example of a "really cool" fact that Dr. Patrick would talk about for hours outside of class.

I would also know things that are "the exception". This is especially important in the class. Take an example from a conversation that I had over break with a carrier of Fragile X. She wanted to know if it is possible for her daughter's to show any signs of Fragile X. I explained, that, while it is an X linked disorder (so, daughters should be spared), there is still the "lyon hypothesis" which involves x inactivation--this means that her daughter's good x can inactivate, leaving the daughter with only the "fragile" x. This daughter would show signs of Fragile X.

That is an example of a difference that physicians need to remember.

Finally, listen closely--Dr. Patrick always "gives away" test questions. This is more of an art, but it is important to understand for Dr. Patrick. If he repeats himself with a pause at the end of his statement, it might be good to focus a little more on that subject. Also, if he ever "pimps" the class about something (ESPECIALLY if he isn't lecturing), then I would definately remember the answer to his pimp. This always seems to manifest itself in review sessions when he interupts Dr. Rhodes. If he talks about a "unique" disease in class, remember that stuff. His underlined stuff in his notes is pretty much 50% of his test questions. Don't be suprised, however, when he asks a question (maybe one per test) that has less than a fragment sentence associated with it, and was never said in class--this is common on all of his tests.

I hope this stuff makes sense--good luck.

erik


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